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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NKX2-1 All Species: 18.18
Human Site: S14 Identified Species: 40
UniProt: P43699 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P43699 NP_001073136.1 371 38596 S14 H T T P F S V S D I L S P L E
Chimpanzee Pan troglodytes XP_509911 401 41649 S44 H T T P F S V S D I L S P L E
Rhesus Macaque Macaca mulatta XP_001089890 371 38509 S14 H T T P F S V S D I L S P L E
Dog Lupus familis XP_849082 233 24205
Cat Felis silvestris
Mouse Mus musculus P50220 372 38552 S14 H T T P F S V S D I L S P L E
Rat Rattus norvegicus P23441 372 38536 S14 H T T P F S V S D I L S P L E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q90788 294 33054
Frog Xenopus laevis P42587 196 22791
Zebra Danio Brachydanio rerio Q90481 269 30288
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9NLC2 299 33058
Sea Urchin Strong. purpuratus NP_999800 411 44821 A14 Q T T S F S V A D I L T P L E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 91.7 99.1 40.7 N.A. 98.1 98.6 N.A. N.A. 32 30.7 32.6 N.A. N.A. N.A. 26.6 38.4
Protein Similarity: 100 91.7 99.1 46.6 N.A. 98.1 98.6 N.A. N.A. 43.4 40.4 43.4 N.A. N.A. N.A. 40.4 50.3
P-Site Identity: 100 100 100 0 N.A. 100 100 N.A. N.A. 0 0 0 N.A. N.A. N.A. 0 73.3
P-Site Similarity: 100 100 100 0 N.A. 100 100 N.A. N.A. 0 0 0 N.A. N.A. N.A. 0 86.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 55 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 55 % E
% Phe: 0 0 0 0 55 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 46 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 55 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 55 0 0 55 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 46 0 0 0 0 0 0 0 0 55 0 0 % P
% Gln: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 10 0 55 0 46 0 0 0 46 0 0 0 % S
% Thr: 0 55 55 0 0 0 0 0 0 0 0 10 0 0 0 % T
% Val: 0 0 0 0 0 0 55 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _